Trinidazole--a new preparation for Trichomonas vaginalis infections. I. Laboratory evaluation.
نویسندگان
چکیده
Tinidazole is a potent member of a new series of nitroimidazoles which are being used as antibiotics (Howes, Lynch, and Kivlin, 1970). The formula is: ethyl (2-(2-methyl-5-nitro-1-imidazolyl) ethyl) sulphone. Nothing has been published about the effect of tinidazole on strains of Trichomonas vaginalis isolated from clinical infections. A laboratory study of the relative efficacy of tinidazole and metronidazole against strains of T. vaginalis from patients and the serum level of tinidazole after its ingestion in a single dose are the subjects of this study.
منابع مشابه
Epidemiology of infections with Trichomonas vaginalis in the light of improved diagnostic methods.
Human genital trichomoniasis has. received a good deal of Attention in recent years, but there are still many aspects of this disease which need fuller investigation. This paper, based on work carried out at the London Hospital during the past 2i years, is offered as an aid in elucidating certain of the more important of these problems-namely, the incidence, mechanism of infection, cause of rel...
متن کاملClinical and Laboratory Testing for Trichomonas vaginalis Infection.
Trichomonas vaginalis infection is highly prevalent in the United States and worldwide. Traditional clinical diagnostic methods fail to identify more than half of these infections that, if left untreated, can result in adverse pregnancy outcomes and an exacerbated risk of both acquisition and transmission of HIV. Women bear a disproportionate amount of the burden of these infections, and testin...
متن کاملDetection of Trichomonas vaginalis on modified Columbia agar in the routine laboratory.
Broth culture of Trichomonas vaginalis is considered the "gold standard" for the diagnosis of trichomoniasis. Two studies were carried out to evaluate modified Columbia agar (MCA) for the isolation of T. vaginalis from clinical samples. Study I compared isolation on MCA to that on liquid medium with 889 vaginal samples. Out of 63 samples positive for T. vaginalis (7.1% of total), MCA identified...
متن کاملDevelopment of PCR assays for detection of Trichomonas vaginalis in urine specimens.
Trichomonas vaginalis infections are usually asymptomatic or can result in nonspecific clinical symptoms, which makes laboratory-based detection of this protozoan parasite essential for diagnosis and treatment. We report the development of a battery of highly sensitive and specific PCR assays for detection of T. vaginalis in urine, a noninvasive specimen, and development of a protocol for diffe...
متن کاملPrevalence of Trichomonas Vaginalis in Diabetic Females
Abstract Background and Objective: Trichomonas vaginalis is a pathogenic agent known worldwide and affects about 180 million annually. We aimed to investigate the prevalence of Trichomonas vaginalis in diabetic patients referred to diabetic research center. Material and Methods: In this descriptive-analytic study, 215 women referring to the Diabetic Center in Kermanshah Province were invest...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of venereal diseases
دوره 50 2 شماره
صفحات -
تاریخ انتشار 1974